D. Kyle Kim, M.D., Ph.D.

Department of Neurological Surgery
Allegheny General Hospital, Pittsburgh PA.
 
 
Career and Publications
 Allegheny General Hospital
 Department of Neurological Surgery
 420 E. North Ave., Suite 302
 Pittsburgh, PA 15212
Phone   412-359-6200 (work)
Fax   412-359-6615
E-mail kkim@wpahs.org
 

Education

 BA 1982 College of the University of Chicago
  General Studies in the Humanities  with honors
 Ph.D 1988 Immunology  Pritzker School of Medicine,
  University of Chicago
 M.D. 1989 Pritzker School of Medicine
  University of Chicago
 

AwardslHonorslGrants

1978-1982 Amos Alonzo Stagg Scholarship
 (full tuition, four-year scholarship)

 Abraham L. Harris Achievement Award
 (scholar- athlete award)

1984-1989 NIH Grant PHS5T32HD-0700 9-14
 (M.D.-Ph.D trainee fellowship)

1987 Pauline and John Roesing Fellowship Grant
  (research fellowship grant)

1995-1997 American Association of Neurological
 Surgeons Research Fellowship Grant 

1995-1997 Pfizer Post-Doctoral Fellowship Grant

1999-2002 NIH K08 NS02025-01

1999-2001 American Heart Association, Beginning
 Grant-In-Aid 

 Medical Licensure
  State of Washington 29378
  State of Pennsylvania 063934

Positions
 1990-1993 Resident in Neurological Surgery
  University of Washington, Seattle, WA

 1992-1993 Chief Resident in Neurological Surgery
  Seattle Children's Hospital,
  Seattle Veteran's Administration Hospital

 1993-1994 Registrar in Neurological Surgery
  Atkinson Moreley's Hospital, 
  Wimbleton England

  1994-1995 Chief Resident in Neurological Surgery
   University of Washington and 
   Harborview Medical Center, Seattle

1996-1997 Acting Instructor in Neurological Surgery
 Post-Doctoral Fellow, Department of Pharmacology
 University of Washington, Seattle, WA

7/97-12/97 Fellow in Cerebrovascular Surgery
 University of Washington, Seattle, WA

1 / 1998- present Assistant Professor, Department of Neurosurgery
 Director, Cerebrovascular Research
 Director, Neurointensive Care Unit
 Head, Neurovascular and Skull Base Surgery
 Allegheny General Hospital, Pittsburgh, PA
 MCP-Hahenemann School of Medicine

Publications:

1. Kim DK, Havran WL, Moldwin RL, Lancki DW, Fitch FW. 1985. IL-2 regulates IL-2 receptor expression on murine T cell clones. ICSU Short Reports 2:195-196.

2. Havran WL, Kim DK, Moldwin RL, Lancki DW, Fitch FW. 1986. IL-2 differentially regulates IL-2 receptors on murine cloned cytolytic and helper T cells. Clin. Immunol. Immunopathol. 39:368-378.

3. Fitch FW, Moldwin RL, Lancki DW, Herold KC, Otten G, Havran W L, Kim DK. 1986. Regulation of activation of cloned murine T cells. Prog. Immunol. 6:396-400.

4. Kim DK, Otten G, Moldwin RL, Dunn D, Nau GJ, Fitch FW. 1986. PMA alone induces proliferation of some murine T cell clones but not others. J. Immunol. 137:2755-2760.

5. Skias DD, Kim DK, Reder AT, Antel JP, Lancki DW, Fitch FW. 1987. Susceptibility of astrocytes to Class I MHC antigen restricted cytotoxicity. J. Immunol. 138:3254--258.

6. Nau GL Moldwin RL, Lancki DW, Kim DK, Fitch FW. 1987. Inhibition of IL=2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody. J. Immunol. 139:114-122.

7. Moldwin RL, Havran WL, Nau GJ, Lancki DW, Kim DK, Fitch FW. 1987. Antibodies to the L3T4 and Lyt-2 molecules interfere with antigen receptor-driven activation of cloned murine T cells. J. Immunol. 139:657-664.

8. Kim DK, Nau GJ, Lancki DW, Dawson G, Fitch FW. 1988. Cholera toxin discriminates between murine T lymphocyte proliferation stimulated by activators of protein kinase C and proliferation stimulated by IL-2: Possible role for intracellular cAMP. J. Immunol. 139:3429-3437.

9. Nau GJ, Kim DK, Fitch FW. 1988. Agents that mimic antigen receptor signaling inhibit proliferation of cloned murine T lymphocytes induced by IL-2. J. Immunol. 141:3557-3563.

10. Kim DK. Mechanisms of Signal Transduction in Murine T Cell Clones. 1988. Thesis, Pritzker School of Medicine, University of Chicago.

11. Kim DK, Lancki DW, Hui FH, Fitch FW. 1989. Protein kinase Cdependent and -independent mechanisms of cloned murine T cell proliferation: The role of protein kinase C translocation and protein kinase C activity. J. Immunol. 142:616-622.

12. Kim DK, Hoyt J, Bacchi C, Keles GE, Mass M, Mayberg MR, Berger M. 1993. Detection of proliferating cell nuclear antigen (PCNA) in gliomas and adjacent resection margins. Neurosurg. 33:619-626.

13. Kim DK, Mayberg MR, Eskridge JM, Newell DW, Winn HR. 1993. Reversal of acute ischemic hypodense lesions on computed tomography. J. Stroke Cerebrovasc. Dis. 3:240-243.

14. Kim DK, Borne D, Mayberg MR, 1994.  Unilateral vestibular schwannoma
in a child with prior orbital rhabdomyosarcoma. Surg. Neurol. 42:125-129.

15. Kim DK. Uttley D, Bell BA, Marsh HT, Moore Aj. 1994. Comparison of rates of infection of two methods of emergency ventricular drainage. J. Neurol. Neurosurg. Psych. 58:444-446.

16. Hoyt JW, Gown AM, Kim DK, Berger MS. 1995. Analysis of proliferative grade in glial neoplasms using antibodies to the Ki-67 defined antigen and PCNA in formalin fixed, deparaffinized tissues. J. Neuro-onc 24:163-169.

17. Eskridge JD, McAuliffe WB, Harris AB, Kim DK, Scott J, Winn HR. 1996. Preoperative endovascular embolization of craniospinal hemangioblastomas. A. J. N. R. 17:525-531.

18. Avellino AM, Kim DK, Weinberger E, Roberts TS. 1996. Resolution of spinal syringes and Chiari I in a child. J. Neurosurg. 84:708-709.

19. Rettig J, Sheng ZH, Kim DK, Catterall WA. 1996. Isoform-specific interaction of a1A subunit of the brain calcium channel with the presynaptic proteins, syntaxin and SNAP-25. Proc. Natl. Acad. Sci USA 93:7363-7368.

20. Britz GW, Kim DK, Loeser JD. 1996. Hydrocephaus secondary to diffuse villous hyperplasia of the choroid plexus: Case report and review of the literature. J. Neurosurg. 85:689-91.

21. Kim DK, Grieve J, Archer D, Uttley D. 1996. Fronto-zygomatic approach to cavernous sinus meningiomas: A review of 21 patients. Brit. J. Neurosurg. 10:439-444.

22. Coplin W, Kim DK, Bird T, Kliot M. 1997. Mutism in an adult following hypertensive cerebellar hemorrhage. Brain and Language 59:473-493.

23. Kim DK, Eskridge JD, Mayberg MR. 1997. Progressive aneurysmal degeneration of a draining vein associated with a dural AVM. Neurosurg 41:673-676.

24. Kim DK, Catterall WC. 1997. Ca2+-dependent and -independent interactions of the isoforms of the [allpha]1A subunit of brain Ca2 channels with presynaptic SNARE proteins. Proc. Natl. Acad. Sci USA. 94:14782-14786.

25. Britz G, Kim DK, Mayberg MR. 1998. Traumatic leptomeningeal cyst in an adult: A case report and review of the literature. Surg. Neurol. 50:465-469.

26. Mochida S, Yokoyama CT, Kim DK, Itoh K, Catterall WA. 1998. Evidence for a voltage-dependent enhancement of neurotransmitter release mediated via the synaptic protein interaction site of N-type Ca2+ channels. Proc Natl Acad Sci USA 95:14523-14528.

27. Kim DK, Mayberg MR. 1999. Symptomatic randomized trials completed and in progress. In CM Loftus, TF Kresowik (eds). Textbook of Carotid Artery Sur erv. Thieme Medical Scientific Publishers, New York.

28. Kim DK. 1999. Miscellaneous neurosurgical techniques relevant to the otolaryngologist. In MArriaga, JD Day (eds). Neurosurgical Issues in Otolaryngology. Lippincott, Williams, and Wilkins. pp 139-150.

29. Coplin WM, Avellino AM, Kim DK, Bybee HM, Jones DT, Dolph RL, Grady MS. 1999. Lumber drain- associated bacterial meningitis: A retrospective epidemiological study. J. Neurosurg. Neurol. Psych. 67:46873.

Kim DK, Ngyuen L, Janigro D, Newell Dm. 2000. P2X receptor antagonists protect against ischemic damage in organotypic hippocampal slice cultures. Submitted.
 

Abstracts and Presentations

1. Havran WL, Kim DK, Moldwin RL, Lancki DW, Fitch FW. 1985. IL-2 causes increased expression of IL-2 receptors on cloned murine T cells. Fed. Proc. 44:950.

2. Otten, G., Fitch FW, Kim DK. 1985. Two T cell clones respond differently to antigen after

3. Kim DK, Moldwin RL, Lancki DW, Fitch FW. 1986. Murine cloned CTL may proliferate via both IL-2 dependent and IL-2 independent pathways. I.C.I. 6:305.

4. Kim DK, Moldwin RL, Fitch FW. 1986. Some but not all T cell clones proliferate in response to PMA alone. Fed. Proc. 45:506. 

5. Skias D, Kim D, A. Reder, B. G. W. Arnason, and J. Antel. 1986. Kinetics of gamma-interferon (IFN gamma) induced expression of Class I major histocompatability (MHC) antigens on cultured murine astrocytes. Fed. Proc. 45:333.

6. Skias, D, Kim DK, A. Reder, Fitch FW, Antel J. 1986. In vitro susceptibility of glial cells to cell-mediated cytotoxicity. American Academy of Neurology Meeting, 1986.

7. Nau GJ, Moldwin RL, Lancki DW, Kim DK, Fitch FW. 1987. Inhibition of IL-2-driven proliferation of T lymphocyte clones by supraoptimal concentrations of immobilized anti-T cell receptor monoclonal antibody. Fed. Proc. 46:459.

8. Nau GJ, Kim DK, Fitch FW. 1988. Agents that mimic antigen receptor signalling can inhibit IL-2-driven proliferation of cloned murine T cells. The Twenty-Seventh Midwinter Conference of Immunologists, 1988.

9. Kim DK, Lancki DW, Hui FH, Fitch FW. 1989. PKC-dependent and independent mechanisms of cloned murine T cell proliferation. FASEB J. 3:A517.

10. Lancki DW, Kaper BP, CS Hsieh, Kim DK, Nau GJ, Fitch FW. 1989. Cytolytic effector mechanisms of murine T cell clones. FASEB J. 3:A1267.

11. Kim DK, AM Lam, BF Matta, TS Mayberg, DW Newell, FIR Winn. Intraoperative transcranial Doppler monitoring of the resection of cerebral AVM's. 1997. Poster Session, American Association of Neurological Surgeons Meeting.

12. Kharlamov A, Kim DK, Jones SC. Reflective change on unprocessed cryostat brain sections and NLAY2 immunoreactivity indicate similar ischemic regions. Soc Neurosci 2000 Meeting (Submitted).

Other Presentations

1. "Acute Management of Stroke" to Somerset Hospital Grand Rounds, April 22, 1998.

2.  "Vascular Malformations", AGH Grand Rounds, September 16,1998.

3. "Surgical Treatment of Stroke", Trinity Health System Grand Rounds, October 19, 1998.

4. "Surgical Treatment of Stroke", Brookville Hospital Grand Rounds October 28, 1998.

5. "Acute Care of the Stroke Patient", DuBois Emergency Medicine Update, November 6, 1998.

6. "Surgical Management of Stroke" Allegheny County Medical Society, November 10, 1998.

7. Annual Basic Science Lecture to AGH general surgery residents " Intracranial Physiology", February 17, 1999.

8. "Surgical Treatment of Stroke" to Butler County Medical Society, January 12,1999.

9. "Acute Management of Stroke" to Somerset Hospital Grand Rounds, April 27, 1999.

10. "Stroke", Medical Frontiers, KDKA Radio November 3, 1999.

11. "Update on Head Injury and Stroke", DuBois Emergency Medicine Update, November 11, 1999.

12. "Update on Neurosurgery", Trinity Health System Grand Rounds, December 6, 1999.

13. "Dear Doc" column ("Spinal Stenosis"), Pittsburgh Post-Gazette, December 26,1999.

14. Annual Basic Science Lecture to AGH general surgery residents "Intracranial Physiology", February 16, 2000.

15. "Brain aneurysms", VVTAE News, March 20, 2000.
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