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Director, Neurosurgical and Spine Research
Associate Professor, Drexel University College of Medicine

Boyle C. Cheng, PhD


Clinical Research Nurse
Diane Cantella, RN

Clinical Research Nurse
Lynn Fletcher, RN, CCRC

Boyle C. Cheng, PhD

Boyle C. Cheng, PhD
Director, Neurosurgical and Spine Research
Associate Professor, Drexel University College of Medicine


BS Mechanical Engineering – Colorado State University – 1991
MS Mechanical Engineering – Colorado State University – 1993
PhD Mechanical Engineering –University of Wisconsin – 1999

Select Publications

Refereed Articles

Deguchi M, Cheng BC, Sato K, Matsuyama Y, Zdeblick TA. Biomechanical evaluation of
translaminar facet joint fixation. A comparative study of poly-L-lactide pins, screws, and
pedicle fixation. Spine 23:1307-12; discussion 1313, 1998.

Mihara H, Cheng BC, David SM, Ohnari K, Zdeblick TA. Biomechanical comparison of
posterior cervical fixation. Spine 26:1662-7, 2001.

Mihara H, Onari K, Cheng BC, David SM, Zdeblick TA. The biomechanical effects of
spondylolysis and its treatment. Spine 28:235-8, 2003.

Welch WC, Cheng BC, Awad TE, Davis R, Maxwell JH, Delamarter R, Wingate JK,
Sherman J, Macenski MM. Clinical Outcomes of the Dynesys Dynamic Neutralization
System: One-Year Preliminary Results from a Food and Drug Administration Investigational
Device Exemption Clinical Trial. Neurosurgical Focus 22 (1):E8, 2007.

Cheng BC, Gordan JD, Cheng JS, Welch WC. Immediate Biomechanical Effects of Lumbar
Posterior Dynamic Stabilization above a Circumferential Fusion. Spine 32 (23):2551-7,

Cheng BC, Hafez Cunningham B, Serhan H, Welch WC. Biomechanical Evaluation of
Occipitocervicothoracic Fusion: Impact of Partial or Sequential Fixation. The Spine Journal
8 (5):821-5, 2008. Epub: Jul 19, 2007. (Electronic publication ahead of print)

Jankowitz BT, Atteberry DS, Gerszten PC, Karausky P, Cheng BC, Faught RF, Welch WC.
Effect of Fibrin Glue on the Prevention of Persistent Cerebral Spinal Fluid Leakage after
Incidental Durotomy During Lumbar Spinal Surgery. European Spine Journal 18 (8):1169-
74, 2009.

Cheng BC, Burns P, Pirris S, Welch WC. Load Sharing and Stabilization Effects of Anterior
Cervical Devices. Journal of Spinal Disorders and Techniques 22 (8):571-7, 2009.

Cook DJ and Cheng BC. Development of a Model Based Method for Investigating Facet
Articulation. Journal of Biomechanical Engineering 132 (6):064504-1-6, 2010.

Alcindor D, Oh MY, Baser S, Angle C, Cheng BC, Whiting D. Stimulation of the Globus
Pallidus Internus in a Patient with DYT-1 Positive Primary Generalized Dystonia: A 10-year
Follow-up. Neurosurgical Focus 29 (2):E16, 2010.

Jegapragasan M, Cook DJ, Gladowski D, Kanter A, Cheng BC. Characterization of
Articulation of the Lumbar Facets in the Human Cadaveric Spine using a Facet-Based
Coordinate System. The Spine Journal 11 (4):340-6, 2011.

Cheng BC, Cook DJ, Cuchanski M, Pirris SM, Welch WC. Biomechanical Cyclical Loading
on Cervical Spines without Anterior Column Support. Journal of ASTM International.

Sanborn MR, Balzer J, Gerszten PC, Karausky P, Cheng BC, Welch WC. Laboratory
Investigation: Safety and Efficacy of a Novel Ultrasonic Osteotome Device in an Ovine
Model. Journal of Clinical Neuroscience. (accepted)

Yu A, Siegfried CM, Chew B, Hobbs J, Sabersky A, Jho DJ, Cook DJ, Bellottee JB, Whiting
DM, Cheng BC. Biomechanics of Posterior Dynamic Fusion Systems in the Lumbar Spine:
Implications for Stabilization with Improved Arthrodesis. Journal of Spinal Disorders and
Techniques. (accepted)

Cook DJ, Yeager MS, Cheng BC. Interpedicular Travel in the Evaluation of Spinal Implants:
An Application in Posterior Dynamic Stabilization. Spine. (accepted)

Book Chapters

Welch WC, Gerszten PC, Cheng BC, Maxwell J. Dynesys Spinal Instrumentation System.
Spine Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics and
Engineering, Lewandrowski K-U, Park P, Trantolo DJ, Yaszemski MJ, McLain RF (eds).
Taylor and Francis, New York, 2006.

Cheng BC, Welch WC. Biomechanical Assessment of Spinal Instability and Stabilization.
Spine Radiosurgery. Gerszten PC, Ryu S (eds). Thieme, New York, 2007.

Cheng BC, Welch WC. Biomechanics of Non-fusion Devices. Motion Preservation Surgery
of the Spine: Advanced Techniques and Controversies. Yue J, Bertagnoli R, McAfee P, An H
(eds). Elsevier, Philadelphia, 2008.

Cheng BC. Biomechanics of Normal and Aging Spine. The Comprehensive Treatment of the
Aging Spine: Minimally Invasive and Advanced Techniques. Yue J, Guyer D, Johnson,
Khoo L, and Hochschuler (eds). Elsevier, Philadelphia, 2010.

Bauman J, Cheng BC, Welch WC. Nucleoplasty and Posterior Dynamic Motion Preservation
Systems. Youman’s Neurological Surgery. 6th ed. Vols 1-4 Winn HR and Shaffery C (eds).
Elsevier, Philadelphia, 2011 (in press).

Cook DJ, Yeager MS, Chakraborty S, Whiting DM, Cheng BC. The Performance Envelope
of Spinal Implants Utilizing Thermoplastic Materials. Thermoplastic Elastomers,
Thermoplastic Elastomers, Prof. Adel El-Sonbati (ed.), InTech, ISBN: 978-953-51-0346-2.

Welch WC, Cheng BC, Awad TE, Macenski MM. Dynamic Stabilization of the Lumbar
Spine. Operative Neurosurgical Techniques. Schmidek and Sweet (eds), (submitted).

Book Sections

Cheng BC, Cook DJ; Jegapragasan M; Gladowski D; Whiting DM. Facet Joint Complex
Considerations for Biomechanics of the Lumbar Functional Spinal Unit: An Improved Model
Based Method for Investigating Facet Articulation. In Magjarevic R, Nagel JH, eds. Lim CT,
Goh JCH, section eds. 6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010
Singapore: Springer Berlin Heidelberg:358-61.

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Diane CantellaDiane Cantella, RN
Clinical Research Nurse

Phone: 412.359.3353
Email: dcantell@wpahs.org 

Select Publications

Wilent WB, Oh MY, Buetefisch CM, Bailes JE, Cantella D, Angle C, Whiting DM. Mapping of microstimulation evoked responses and unit activity patterns in the lateral hypothalamic area recorded in awake humans. J NEUROSURG April 15, 2011; DOI: 10.3171/2011.3.JNS101574.

Wilent WB, Oh MY, Buetefisch CM, Bailes JE, Cantella D, Angle C, Whiting DM. Induction of Panic Attack by Stimulation of the Ventromedial Hypothalumus. J NEUROSURG 112:1295-1298, 2010.

Cantella D. Sports-Related Spinal Cord Injury. CRITICAL CARE NURSING QUARTERLY 22(2)14-19, 1999.

Quigley MR, Vidovich D, Cantella D,et al: Defining the Limits of Survivorship after Very Severe Head Injury. J TRAUMA 42:7-10, 1997.

Wilberger JE, Cantella D. High Dose Barbiturates for Intracranial Pressure Control. Society for Critical Care Medicine, New Horizons: THE SCIENCE AND PRACTICE OF ACUTE MEDICINE 3:469-473, 1995.

Quigley MR, Cantella D, Vidovich D, Wilberger J, Maroon JC: Simplified method of predicting outcome following very severe head injury. J NEUROSURG 82:357A, 1995 (#757).

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Lynn Fletcher, RN, CCRC
Clinical Research Nurse

Phone: 412.359.4802
Email: lfletche@wpahs.org 

Select Publications

Jannetta, PJ, Hollihan, L: Type 2 Diabetes Mellitus, Etiology and Possible Treatment: Preliminary Report. Surgical Neurology 61:422-8, May 2004.

Sekula RF, Marchan EM, Fletcher LF, Casey K, Jannetta PJ: Microvascular Decompression for Trigeminal Neuralgia in the Elderly Population. Journal of Neurosurgery, April 2008.

Jannetta PJ, Fletcher LH, Grondziowski PM, Casey KF, Sekula RF. Type 2 diabetes mellitus: A central nervous system etiology. Surg Neurol Int 2010;1:31

Jannetta PJ, Whiting DM, Fletcher L, Hobbs, JK, Brillman J, Quigley M, Fukui M, Williams R: Parkinson’s Disease: An Inquiry into the etiology and treatment. Neurology International 2011; volume 3:e7

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