Research

Breast Cancer Clinical Trials

The following clinical trials related to breast cancer are available through the WPAHS. Please click on the link for more detailed information on the trial. Below each trial is the contact information at the WPAHS.

Ductal Carcinoma In Situ (DCIS)

Study Title

A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently With Radiation Therapy and Radiation Therapy Alone for Women With HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Principal Investigator: Thomas Julian, M.D.

Please also contact study coordinator for more information:

Stephanie Kenney, CRA (Phone 412.359.4856)

Internal Reference: (RC-4701/NSABP B-43 Julian)

Laura Gibson, RN, CCRC (Phone 412.578.4439)

Study Title

A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women With Stage 0, I, or II Breast Cancer

Principal Investigator: Thomas Julian, M.D.

Please also contact study coordinator for more information:

Stephanie Kenney, CRA (Phone 412.359.4856)

Internal Reference: (RC-3881/NSABP B-39 Julian)

Laura Gibson, RN, CCRC (Phone 412.578.4439)

Internal Reference: (IRB 05-04-038-JF/NSABP B-39 Julian)

Stage I and II Breast Cancer

Study Title

Vanderbilt University: Pre-Surgical Trial of Letrozole in Post-Menopausal Patients with Operable Hormone-Sensitive Breast Cancer

Principal Investigator: Thomas Julian, M.D.

Please also contact study coordinator for more information:

Stephanie Kenney, CRC (Phone 412.359.4856)

Internal Reference: (RC-4792/Vanderbilt Julian)

Study Title

A Clinical Study to Test the Feasibility of Detection and Characterization of Circulating Tumor Cells With Imaging Flow Cytometry

***Please contact Elaine for more information on this specific trial***

Principal Investigator: Charles Geyer, M.D.

Please also contact study coordinator for more information:

Elaine Kimmel, RN, MSN (Phone 412.359.8458)

Internal Reference: (RC-5254/NSABP CTC-01 Geyer)

Stage II, IIIA, and IIIB Breast Cancer

Study Title

Z1071: A Phase II Study Evaluating the Role of Sentinel Lymph Node Surgery and Axillary Lymph Node Dissection Following Preoperative Chemotherapy in Women with Node Positive Breast Cancer (T0-4, N1-2, M0) at Initial Diagnosis

Principal Investigator: Thomas Julian, M.D.

Please also contact study coordinator for more information:

Gloria Flannery, RN (Phone 412.359.8379)

Internal Reference: (RC-5058/CTSU/ACOSOG Julian)

Invasive Breat Cancer

Study Title

ACTS: The ACTS Intervention to Reduce Breast Cancer Treatment Disparities

Principal Investigator: Jane Raymond, M.D.

Please also contact study coordinator for more information:

Stephanie Kenney, CRC (Phone 412.359.4856)

Internal Reference: (RC-5053/ACTs Raymond)

Locally Advanced Recurrent Breast Cancer

Study Title

A Phase II Trial to Evaluate Breast Conservation Surgery and Partial Breast Radiotherapy in the Management of Locally Recurrent Carcinoma of the Breast

Principal Investigator: Mark Trombetta, M.D.

Please also contact study coordinator for more information:

Judy Negley, CCRP (Phone 412.359.4046)

Internal Reference: ( RC4686/Radiation Oncology Dept. Trombetta)

Study Title

NSABP FB-7: A Phase II Randomized Clinical Trial Evaluating Neoadjuvant Therapy Regimens with Weekly Paclitaxel and Neratinib or Trastuzumab Followed by Doxorubicin and Cyclophosphamide with Postoperative Trastuzumab in Women with Locally Advanced HER2-Positive Breast Cancer

Principal Investigator: Thomas Julian, M.D.

Please also contact study coordinator for more information:

Sandy Brown, RN, OCN (Phone 412.359.6408)

Internal Reference: (RC-5154/NSABP FB-7 Julian)

Metastatic Breast Cancer

Study Title

An Open-Label, Expanded Access Protocol for Patients with ER-, PR-, and HER2-Negative Metastatic Breast Cancer

Principal Investigator: Charles Geyer, M.D.

Please also contact study coordinator for more information:

Sandy Brown, RN, OCN (Phone 412.359.6408)

Internal Reference: (RC-5023/Geyer)

Her- 2 Breast Cancer Trials

Study Title

A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six cycles of Docetaxel Plus cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer

Principal Investigator: Thomas Julian, M.D.

Please also contact study coordinator for more information:

Sandy Brown, RN, OCN (Phone 412.359.6408)

Internal Reference: (RC-5196/NSABP B-47 Julian)

Study Title

A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

Principal Investigator: Thomas Julian, M.D.

Please also contact study coordinator for more information:

Gloria Flannery, RN (Phone 412.359.8379)

Internal Reference: (RC-4845/NSABP B-46-I Julian)

Rich Wonder, RN, CCRC (Phone 412.578.4492)

Laura Gibson, RN, CCRC (Phone 412.578.4439)

Study Title

A Randomized Phase III Trial of Neoadjuvant Therapy in Patients With Palpable and Operable Breast Cancer Evaluating the Effect on Pathologic Complete Response (pCR) of Adding Capecitabine or Gemcitabine to Docetaxel When Administered Before AC With or Without Bevacizumab and Correlative Science Studies Attempting to Identify Predictors of High Likelihood for pCR With Each of the Regimens

Principal Investigator: Thomas Julian, M.D. and Helen Analo, M.D.

Please also contact study coordinator for more information:

This trial is offered at both Allegheny General and Western Pennsylvania Hospital.

Please also contact study coordinator for more information:

AGH

Sandy Brown, RN, OCN (Phone 412.359.6408)

Internal Reference: (RC-4405/NSABP B-41 Julian)

Rich Wonder, RN, CCRC (Phone 412.578.4492)

Laura Gibson, RN, CCRC (Phone 412.578.4439)

Internal Reference: (WPCI 2007-24/NSABP B-41 Analo)